Which type of substance is typically avoided with peripheral intravenous access?

Chemotherapeutic agents are typically avoided with peripheral intravenous access due to their potential for causing local tissue damage and extravasation injuries. These agents can be irritating or toxic to the surrounding tissue, which is more of a concern when administered through a peripheral line where there is a higher risk of leakage. If extravasation occurs, it can lead to severe complications such as inflammation, pain, or necrosis, depending on the specific agent involved.

In contrast, substances like normal saline, antibiotics, and electrolyte solutions are often administered through peripheral lines because they are generally well-tolerated and less likely to cause harm if extravasated. Normal saline is a standard fluid for hydration and is commonly used; antibiotics are critical for infection management and can usually be given safely in this manner; electrolyte solutions are essential for balancing electrolytes and are also typically used in peripheral IV access. Thus, chemotherapeutic agents stand out as substances that necessitate careful administration often through central lines, where monitoring and management of potential complications can be more effectively controlled.