Which category of anti-hypertensives suppresses the renin-angiotensin-aldosterone system?

The correct answer is ACE inhibitors. These medications work by blocking the enzyme known as angiotensin-converting enzyme (ACE), which plays a critical role in the renin-angiotensin-aldosterone system (RAAS). This system is responsible for regulating blood pressure and fluid balance within the body.

When the RAAS is activated, it leads to the production of angiotensin II, a potent vasoconstrictor that increases blood pressure, and stimulates the secretion of aldosterone, which promotes sodium and water retention. By inhibiting ACE, these drugs prevent the conversion of angiotensin I to angiotensin II, resulting in vasodilation and decreased blood pressure. Additionally, by reducing aldosterone levels, ACE inhibitors promote diuresis and help decrease fluid overload, which further contributes to lowering blood pressure.

While angiotensin receptor blockers (ARBs), another class of antihypertensives, also target the RAAS by blocking the action of angiotensin II directly at its receptor sites, the question specifically asks for the category that suppresses the RAAS directly through enzyme inhibition, which is the primary action of ACE inhibitors. This distinction is important for understanding the mechanisms of different antihypertensive classes and their clinical applications