What is the volume range for total drug delivery during TACE/SIRT?

In transarterial chemoembolization (TACE) and selective internal radiation therapy (SIRT), the volume used for total drug delivery is crucial for effective disease management, particularly in treating liver tumors. The correct range of 24-30 ml typically represents the volume required to ensure adequate delivery of the therapeutic agents while maintaining the desired balance between efficacy and safety.

This volume is important because it allows for the effective embolization of the target tumor vasculature while minimizing the risk of complications such as non-target embolization or damage to adjacent tissues. The goal in TACE and SIRT is to achieve a sufficient concentration of the chemotherapeutic agent or radioactive particles within the tumor, which requires the delivery of a specific volume that can adequately saturate the target area.

Volumes lower than this range may lead to inadequate local control, while volumes above it could increase the probability of adverse effects and systemic complications. Therefore, understanding this volume range is essential for practitioners in the field of interventional radiology to optimize treatment outcomes in patients undergoing these therapies.