What is the main effect of fibrates?

Fibrates primarily function by decreasing the synthesis of triglycerides in the liver, leading to lower triglyceride levels in the bloodstream. They activate peroxisome proliferator-activated receptors (PPARs), which are involved in lipid metabolism. This activation promotes the oxidation of fatty acids and enhances the uptake of triglyceride-rich lipoproteins by tissues, effectively reducing triglyceride levels.

Additionally, fibrates can have a modest effect on increasing high-density lipoprotein (HDL) cholesterol and decreasing low-density lipoprotein (LDL) cholesterol levels. However, their most significant and defining characteristic is their ability to lower triglyceride levels, making them particularly useful for patients who experience hypertriglyceridemia and associated risks.

Other options highlight different aspects of lipid metabolism but do not encapsulate the primary action of fibrates as accurately as the correct answer.