What is a primary cause of abdominal aortic aneurysm (AAA)?

Smoking is identified as a primary cause of abdominal aortic aneurysm (AAA) due to its significant impact on the vascular system. The harmful substances in tobacco smoke contribute to the degeneration of the vascular walls, increasing inflammation, promoting atherosclerosis, and weakening the structural integrity of the aorta. Chronic tobacco use is associated with the development and enlargement of aneurysms, making it a critical risk factor in the pathogenesis of AAA.

In contrast, regular exercise tends to promote cardiovascular health and is generally associated with a lower risk of vascular diseases, including AAA. A history of vascular surgery does not inherently cause an AAA but may be related to vascular health issues. Adhering to a low cholesterol diet can be beneficial for overall vascular health and management of atherosclerotic disease but does not directly contribute to the formation of an AAA. Hence, smoking stands out as the most significant lifestyle factor linked to the development of abdominal aortic aneurysms.